Boccella N, Yu G, Seaman S, Feng Y, Lee J, Tomassoni-Ardori F, Yang L, Hsu KS, Dunleavey JM, Becker J, Hilton MB, Morris K, Borchin N, So D, Bajgain P, Yanpallewar S, Gross RT, Dewan KC, Bowles DE, Yuen DA, Tessarollo L, St Croix B. ANTXR1 blockade enhances cardiac function in preclinical models of heart failure. Nat Cardiovasc Res. 2025 Oct 2. doi: 10.1038/s44161-025-00725-y.

He X, Ballestas ER, Zeng L, Zhang T, McEvoy CM, Misra PS, Ki V, Apostol A, Wong JS, Meliambro K, Ray J, De Cos M, Melica ME, Romagnani P, Feng Y, Krizova A, How I, Rosales IA, Colvin RB, He JC, Campbell KN, Yuen DA. Podocyte YAP and TAZ hyperactivation drives glomerular epithelial proliferative diseases in mice and humans. Sci Transl Med. 2025 Jun 25;17(804):eadq3852. doi: 10.1126/scitranslmed.adq3852. Epub 2025 Jun 25.

Hysi E, Baek J, Koven A, He X, Ulloa Severino L, Wu Y, Kek K, Huang S, Krizova A, Farcas M, Ordon M, Fok KH, Stewart R, Pace KT, Kolios MC, Parker KJ, Yuen DA. A first-in-human study of quantitative ultrasound to assess transplant kidney fibrosis. Nature Medicine. 2025. epub Mar 3 2025. 10.1038/s41591-024-03417-5

Mitrofanova A, Fontanella AM, Molina J, Zhang G, Mallela SK, Severino LU, Santos J JV, Tolerico M, Njeim R, Issa W, Boulina M, Carrazco A, Semenova V, Zuo Y, Ficarella M, Kim JJ, Sloan A, Sharma K, Yuen DA, Perin L, Burke GW, Fornoni A, Merscher S. The enzyme SMPDL3b in podocytes decouples proteinuria from chronic kidney disease progression in experimental Alport Syndrome. Kidney Int. 2025 Aug;108(2):253-270. doi: 10.1016/j.kint.2025.04.024.

Wu E, Macklin S, Zhang Y, Thai K, Nghiem L, Di Ciano-Oliveira C, Coelho N, Wang H, Advani SL, Desjardins JF, Yuen DA, Misra P, Connelly KA, Nyengaard JR, Gilbert RE. Induction of proximal tubular proliferation and lengthening in response to sodium glucose linked cotransporter-2 inhibition in experimental rats. J Diabetes Investig. 2025 Jul;16(7):1232-1242. doi: 10.1111/jdi.70043.

McEvoy CM, Yuen DA. Not too much, not too little-just the right amount: the story of YAP in the podocyte. Kidney Int. 2024 Jun;105(6):1157-1159. doi: 10.1016/j.kint.2024.02.016.

Ishikita A, Karur GR, Hanneman K, Yuen DA, Chaturvedi RR, Friedberg MK, Epelman S, He X, Roche SL, Wald RM. Myocardial Extracellular Volume Fraction Varies With Hemodynamic Load and After Pulmonary Valve Replacement in TOF. JACC Cardiovasc Imaging. 2024 Jul;17(7):830-832. doi: 10.1016/j.jcmg.2024.02.013. Epub 2024 Apr 17.

Luk CT, Chan CK, Chiu F, Shi SY, Misra PS, Li YZ, Pollock-Tahiri E, Schroer SA, Desai HR, Sivasubramaniyam T, Cai EP, Krishnamurthy M, Han DJ, Chowdhury A, Aslam R, Yuen DA, Hakem A, Hakem R, Woo M. Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation. Diabetes. 2023 Dec 1;72(12):1751-1765. doi: 10.2337/db22-1033.

McEvoy CM, Hu Q, Abe KT, Yau K, Oliver MJ, Levin A, Gingras AC, Hladunewich MA, Yuen DA. Humoral Responses in the Omicron Era Following 3-Dose SARS-CoV-2 Vaccine Series in Kidney Transplant Recipients. Transplant Direct. 2022 Dec 7;9(1):e1401. doi: 10.1097/TXD.0000000000001401

Nangaku M, Kitching AR, Boor P, Fornoni A, Floege J, Coates PT, Himmelfarb J, Lennon R, Anders HJ, Humphreys BD, Caskey FJ, Fogo AB; TRANSFORM group. Kidney Int. 2023 Mar 28:S0085-2538(23)00174-6. doi: 10.1016/j.kint.2023.03.007

Han DJJ, Aslam R, Misra P, Chiu F, Ohja T, Chowdhury A, Chan CK, Sung HK, Yuen DA, Luk CT. Disruption of adipocyte YAP improves glucose homeostasis in mice and decreases adipose tissue fibrosis. Molecular Metabolism 2022. Epub Sept 20, 2022. doi: 10.1016/j.molmet.2022.101594

Shatil AS, Kirpalani A, Younus E, Tyrrell PN, Krizova A, Yuen DA. Magnetic resonance elastography-derived stiffness predicts renal function loss and is associated with microvascular inflammation in kidney transplant recipients. Transplantation Direct 2022; 8(6):e1334.

Zhang T, He X, Caldwell L, Goru SK, Ulloa Severino L, Tolosa MF, Misra PS, McEvoy CM, Christova T, Liu Y, Atin C, Zhang J, Hu C, Vukosa N, Chen X, Krizova A, Kirpalani A, Gregorieff A, Ni R, Chan K, Gill MK, Attisano L, Wrana JL, Yuen DA. NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling. Science Translational Medicine. 2022 Mar 23;14(637):eaaz4028. doi: 10.1126/scitranslmed.aaz4028. Epub 2022 Mar 23.

McEvoy CM, Lee A, Misra PS, Lebovic G, Wald R, Yuen DA. Real-world Impact of 2-dose SARS-CoV-2 Vaccination in Kidney Transplant Recipients. Transplantation. 2022 May 1;106(5):e279-e280. doi: 10.1097/TP.0000000000004081. Epub 2022 Mar 4.

He X, Tolosa MF, Zhang T, Goru SK, Ulloa Severino L, Misra PS, McEvoy CM, Caldwell L, Szeto SG, Gao F, Chen X, Atin C, Ki V, Vukosa N, Hu C, Zhang J, Yip C, Krizova A, Wrana JL, Yuen DA. Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis. JCI Insight. 2022 Feb 22;7(4):e146243. doi: 10.1172/jci.insight.146243.

Chen A, Ulloa Severino L, Panagiotou TC, Moraes TF, Yuen DA, Lavoie BD, Wilde A. Inhibition of polar actin assembly by astral microtubules is required for cytokinesis. Nature Communications 2021; doi: 10.1038/s41467-021-22677-0.

Xu J, Salari A, Wang Y, He X, Kerr L, Darbandi A, de Leon AC, Exner AA, Kolios MC, Yuen D, Tsai SH. Microfluidic Generation of Monodisperse Nanobubbles by Selective Gas Dissolution. Small 2021; doi: 10.1002/smll.202100345.

Hysi E, Yuen DA. Imaging of renal fibrosis. Curr Opin Nephrol Hypertens. 2020 Nov;29(6):599-607. doi: 10.1097/MNH.0000000000000650.

Gilbert RE, Caldwell L, Misra PS, Chan K, Burns KD, Wrana JL, Yuen DA. Overexpression of the SARS-CoV-2 receptor, ACE-2, in diabetic kidney disease: implications for kidney injury in Covid-19. Canadian Journal of Diabetes. 2020 Aug online ahead of print. doi: 10.1016/j.jcjd.2020.07.003

Misra PS, Szeto SG, Krizova A, Gilbert RE, Yuen DA. Renal histology in diabetic nephropathy predicts progression to end-stage kidney disease but not the rate of renal function decline. BMC Nephrology 2020; 21: 285. doi: 10.1186/s12882-020-01943-1.

Hashim E*, Yuen DA*, Kirpalani A. Reduced flow in delayed graft function as assessed by IVIM is associated with time to recovery following kidney transplantation. J Magn Reson Imaging 2020 June 29. doi: 10.1002/jmri.27245.  *CO-FIRST AUTHORS

Tangri N, Ferguson TW, Wiebe C, Eng F, Nash M, Astor BC, Lam NN, Ye F, Shin JI, Whitlock R, Yuen DA. Validation of the Kidney Failure Risk Equation in Kidney Transplant Recipients. Can J Kidney Health Dis 2020 May 25;7:2054358120922627. doi: 10.1177/2054358120922627. eCollection 2020.

Hysi E, He X, Fadhel MN, Zhang T, Krizova A, Ordon M, Farcas M, Pace KT, Mintsopoulos V, Lee WL, Kolios M, Yuen D. Photoacoustic imaging of kidney fibrosis for assessing pre-transplant organ quality. JCI Insight. 2020 Apr 16. pii: 136995. doi: 10.1172/jci.insight.136995

He X, Zhang T, Tolosa M, Goru SK, Chen X, Misra PS, Robinson LA, Yuen DA. A new, easily generated mouse model of diabetic kidney fibrosis. Sci Rep. 2019 Aug 29;9(1):12549. doi: 10.1038/s41598-019-49012-4.

Yamamura K, Yuen D, Hickey EJ, He X, Chaturvedi RR, Friedberg MK, Grosse-Wortmann L, Hanneman K, Billia F, Farkouh ME, Wald RM. Right ventricular fibrosis is associated with cardiac remodelling after pulmonary valve replacement. Heart. 2019 Jun;105(11):855-863. doi: 10.1136/heartjnl-2018-313961

Kepecs DM, Glick L, Silver SA, Yuen DA. Does Chronic Kidney Disease-Induced Cognitive Impairment Affect Driving Safety? Can J Kidney Health Dis. 2018 Jun 17;5:2054358118777133. doi: 10.1177/2054358118777133. eCollection 2018.

Kirpalani A, Hashim E, Leung G, Kim JK, Krizova A, Jothy S, Deeb M, Jiang NN, Glick L, Mnatzakanian G, Yuen DA. Magnetic Resonance Elastography to Assess Fibrosis in Kidney Allografts. Clin J Am Soc Nephrol. 2017 Oct 6;12(10):1671-1679.

Kim JK, Yuen DA, Leung G, Jothy S, Zaltzman J, Ramesh Prasad GV, Prabhudesai V, Mnatzakanian G, Kirpalani A.  Role of Magnetic Resonance Elastography as a Noninvasive Measurement Tool of Fibrosis in a Renal Allograft: A Case Report.  Transplant Proc. 2017 Sep;49(7):1555-1559.

Misra P, Kirpalani A, Leung G, Vlachou PA, Lee JY, Jothy S, Zaltzman J, Yuen DA.   The role of thrombectomy and diffusion-weighted imaging with MRI in post-transplant renal vein thrombosis: a case report. BMC Nephrol. 2017 Jul 10;18(1):224

Sarak B, Wald R, Goldstein MB, Deva DP, Leipsic J, Kiaii M, Leung G, Barfett JJ, Perl J, Yuen DA, Connelly KA, Yan AT.  Relationship between changes in blood pressure and left ventricular mass over 1 year in end-stage renal disease.  J Hypertens. 2017 Aug;35(8):1709-1716.

Leung G, Kirpalani A, Szeto SG, Deeb M, Foltz W, Simmons CA, Yuen DA.  Could MRI Be Used To Image Kidney Fibrosis? A Review of Recent Advances and Remaining Barriers. Clin J Am Soc Nephrol. 2017 Jun 7;12(6):1019-1028

Ross BA, Wald R, Goldstein MB, Yuen DA, Leipsic J, Kiaii M, Rathe A, Deva DP, Kirpalani A, Bello OO, Graham JJ, Leong-Poi H, Connelly KA, Yan AT. Relationships Between Left Ventricular Structure and Function According to Cardiac MRI and Cardiac Biomarkers in End-Stage Renal Disease.  Can J Cardiol. 2017 Apr;33(4):501-507.

Auguste BL, Yuen DA, Chan CT: Conventional hemodialysis is associated with greater bone loss than nocturnal hemodialysis: a retrospective observation study of a convenience cohort. Can J Kidney Health Dis 2016; 3: 27. 

Szeto SG, Narimatsu M, Lu M, He X, Sidiqi AM, Tolosa MF, Chan L, De Freitas K, Majumder S, Boo S, Hinz B, Dan Q, Advani A, John R, Wrana JL, Kapus A, Yuen DA: YAP and TAZ are mechanoregulators of TGF-b Smad signaling and renal fibrogenesis. J Am Soc Nephrol 2016 epub March 9 2016.

Yuen DA, Huang YW, Liu GY, Patel S, Fang F, Zhou J, Thai K, Sidiqi A, Szeto SG, Chan L, Lu M, He X, John R, Gilbert RE, Scholey JW, Robinson LA: Slit2 inhibits TGF-b-induced fibroblast activation and renal fibrosis in mice. J Am Soc Nephrol 2016; epub Feb 11.

Yuen DA, Kepecs D, Zhang Y, Thai K, Connelly KA, Advani A, Gilbert RE. Repeated treatment with progenitor cell secretory products maintains long-term renoprotection in experimental chronic kidney disease. Can J Kidney Health Dis 2015; 2:44. 

Rozycki M, Bialik JF, Speight P, Dan Q, Szeto S, Yuen D, Szaszi K, Pedersen SF, Kapus A: Myocardin-related transcription factor regulates Nox4 expression: linking cytoskeletal organization to redox state. J Biol Chem 2015 Nov 10 epub.

Lineen JR, Kuliszewski M, Dacouris N, Liao C, Rudenko D, Deva DP, Goldstein M, Leong-Poi H, Wald R, Yan AT, Yuen DA. Early outgrowth pro-angiogenic cell number and function do not correlate with left ventricular structure and function in conventional hemodialysis patients: a cross-sectional study. Can J Kidney Health Dis 2015; 2:15 

Kepecs DM, Zhang Y, Thai K, Advani SL, Yuen DA, Connelly KA, Kosanam H, Diamandis E, Sefton MV, Gilbert RE.Application of Modular Therapy for Renoprotection in Experimental Chronic Kidney Disease.Tissue Eng Part A. 2015 Mar 20.

Molnar MZ, Prasad GV, Yuen DA, Jothy S, Zaltzman JS. A clinical and pathological variant of acute transplant glomerulopathy. Case Rep Pathol. 2014;2014:961987. doi: 10.1155/2014/961987. Epub 2014 Sep 11. 

Chen LH, Advani SL, Thai K, Kabir MG, Sood MM, Gibson IW, Yuen DA, Connelly KA, Marsden PA, Kelly DJ, Gilbert RE, Advani A.SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease. PLoS One. 2014 Mar 17;9(3):e92227. doi: 10.1371/journal.pone.0092227. eCollection 2014.

Molnar AO, Yuen DA, Tangri N, Jensen VL. Bridging the gap: a Canadian perspective on translational kidney research. Can J Kidney Health Dis. 2014 Aug 29;1:18. doi: 10.1186/s40697-014-0018-5. eCollection 2014. 

Yuen DA, Connelly KA, Zhang Y, Advani SL, Thai K, Kabir G, Kepecs D, Spring C, Smith C, Batruch I, Kosanam H, Advani A, Diamandis E, Marsden PA, Gilbert RE.Early outgrowth cells release soluble endocrine antifibrotic factors that reduce progressive organ fibrosis.Stem Cells. 2013 Nov;31(11):2408-19. doi: 10.1002/stem.1502. 

Chaturvedi S*, Yuen DA*, Bajwa A, Huang YW, Sokollik C, Huang L, Lam GY, Tole S, Liu GY, Pan J, Chan L, Sokolskyy Y, Puthia M, Godaly G, John R, Wang C, Lee WL, Brumell JH, Okusa MD, Robinson LA. *CO-FIRST AUTHORS Slit2 prevents neutrophil recruitment and renal ischemia-reperfusion injury. J Am Soc Nephrol. 2013 Jul;24(8):1274-87. doi: 10.1681/ASN.2012090890. Epub 2013 Jun 13.

Yuen DA, Robinson LA.Slit2-Robo signaling: a novel regulator of vascular injury.Curr Opin Nephrol Hypertens. 2013 Jul;22(4):445-51. doi: 10.1097/MNH.0b013e32836235f4. Review.

Yuen DA, Zhang Y, Thai K, Spring C, Chan L, Guo X, Advani A, Sivak JM, Gilbert RE.Angiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by SIRT1 activation. Stem Cells Transl Med. 2012 Dec;1(12):921-6. doi: 10.5966/sctm.2012-0026. Epub 2012 Nov 26 

Jakubovic BD, Wald R, Goldstein MB, Leong-Poi H, Yuen DA, Perl J, Lima JA, Liu JJ, Kirpalani A, Dacouris N, Wald R, Connelly KA, Yan AT.Comparative assessment of 2-dimensional echocardiography vs cardiac magnetic resonance imaging in measuring left ventricular mass in patients with and without end-stage renal disease.Can J Cardiol. 2013 Mar;29(3):384-90. doi: 10.1016/j.cjca.2012.07.013. Epub 2012 Oct 25.

Gilbert RE, Zhang Y, Yuen DA.Cell therapy for diabetic nephropathy: is the future, now? Semin Nephrol. 2012 Sep;32(5):486-93. doi: 10.1016/j.semnephrol.2012.07.012. 

Yuen DA, Stead BE, Zhang Y, White KE, Kabir MG, Thai K, Advani SL, Connelly KA, Takano T, Zhu L, Cox AJ, Kelly DJ, Gibson IW, Takahashi T, Harris RC, Advani A. eNOS deficiency predisposes podocytes to injury in diabetes. J Am Soc Nephrol. 2012 Nov;23(11):1810-23. doi: 10.1681/ASN.2011121170. Epub 2012 Sep 20.

Connelly KA, Zhang Y, Advani A, Advani SL, Thai K, Yuen DA, Gilbert RE.DPP-4 inhibition attenuates cardiac dysfunction and adverse remodeling following myocardial infarction in rats with experimental diabetes.Cardiovasc Ther. 2013 Oct;31(5):259-67. doi: 10.1111/1755-5922.12005.

Chen LH, Stead B, Advani SL, Yaqoob N, Thai K, Kabir MG, Yuen DA, Connelly KA, Gilbert RE, Advani A.Hyperglycemia and renal mass ablation synergistically augment albuminuria in the diabetic subtotally nephrectomized rat: implications for modeling diabetic nephropathy. Nephron Extra. 2012 Jan;2(1):115-24. doi: 10.1159/000338272. Epub 2012 May 12. 

Yuen DA, Gilbert RE, Marsden PA.Bone marrow cell therapies for endothelial repair and their relevance to kidney disease. Semin Nephrol. 2012 Mar;32(2):215-23. doi: 10.1016/j.semnephrol.2012.02.008. Review.

Zhang Y*, Yuen DA*, Advani A, Thai K, Advani SL, Kepecs D, Kabir MG, Connelly KA, Gilbert RE. *CO-FIRST AUTHORS Early-outgrowth bone marrow cells attenuate renal injury and dysfunction via an antioxidant effect in a mouse model of type 2 diabetes. Diabetes. 2012 Aug;61(8):2114-25. doi: 10.2337/db11-1365. Epub 2012 May 17.

Petruzziello-Pellegrini TN, Yuen DA, Page AV, Patel S, Soltyk AM, Matouk CC, Wong DK, Turgeon PJ, Fish JE, Ho JJ, Steer BM, Khajoee V, Tigdi J, Lee WL, Motto DG, Advani A, Gilbert RE, Karumanchi SA, Robinson LA, Tarr PI, Liles WC, Brunton JL, Marsden PA.The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice.J Clin Invest. 2012 Feb;122(2):759-76. doi: 10.1172/JCI57313. Epub 2012 Jan 9. 

Advani A, Connelly KA, Yuen DA, Zhang Y, Advani SL, Trogadis J, Kabir MG, Shachar E, Kuliszewski MA, Leong-Poi H, Stewart DJ, Gilbert RE.Fluorescent microangiography is a novel and widely applicable technique for delineating the renal microvasculature.PLoS One. 2011;6(10):e24695. doi: 10.1371/journal.pone.0024695. Epub 2011 Oct 3. 

Yuen DA, Kuliszewski MA, Liao C, Rudenko D, Leong-Poi H, Chan CT. Nocturnal hemodialysis is associated with restoration of early-outgrowth endothelial progenitor-like cell function.Clin J Am Soc Nephrol. 2011 Jun;6(6):1345-53. doi: 10.2215/CJN.10911210. Epub 2011 May 19. 

Advani A, Huang Q, Thai K, Advani SL, White KE, Kelly DJ, Yuen DA, Connelly KA, Marsden PA, Gilbert RE. Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism. Am J Pathol. 2011 May;178(5):2205-14. doi: 10.1016/j.ajpath.2011.01.044.

Gilbert RE, Huang Q, Thai K, Advani SL, Lee K, Yuen DA, Connelly KA, Advani A. Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor. Kidney Int. 2011 Jun;79(12):1312-21. doi: 10.1038/ki.2011.39. Epub 2011 Mar 9.

Yuen DA*, Connelly KA*, Advani A, Liao C, Kuliszewski MA, Trogadis J, Thai K, Advani SL, Zhang Y, Kelly DJ, Leong-Poi H, Keating A, Marsden PA, Stewart DJ, Gilbert RE. *CO-FIRST AUTHORS Culture-modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease rat model via a novel antifibrotic mechanism. PLoS One. 2010 Mar 4;5(3):e9543. doi: 10.1371/journal.pone.0009543.